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Evidence is increasing that all addiction without exception is related to issues with the brain's reward center, specially the mesolimbic system. This section of the problem regulates reward responses in establishing food and sex, as well as in nurturing infants and children. One of the most important neurotransmitters involved in reward responses, both after they malfunction and whenever they function properly, is dopamine. What makes opiates unique is that it, among other neurotransmitters modulates "the volume of dopamine released in in response to a stimulus"(Bostwick & Bucci, 2008).

Using two separate drugs to lose weight can be very effective you will find combinations before the FDA now awaiting approval. When dealing with weight-loss and the people who go through it one should err on the side of caution and allow FDA do its job and demand some investigation be done so the public is aware of the side effects and risks of the medications before we drive them. Keep in mind that drug companies will be in business to generate money and that they would say almost anything to keep people on his or her medications.

Researchers found out that participants taking this drug for a year, dropped excess weight within four weeks and have kept the load off through the 56 weeks from the study. Contrave can be a combination with the drugs naltrexone and bupropion, which usually reflect a new trend of weight-loss drugs that are made up of several active ingredient, which can make them more efficient and safer.

Combo-pilling could be the newest fad or better yet the newest to come under scrutiny and therefore it is just more publicly known lately, comb-pilling for weight reduction has been around since the eighties. The biggest reason that using a combination of pills has become popular will be the fact that as of right now there are not any long term prescription slimming capsules that have been licensed by the FDA besides orlistat. The truly disturbing part is the fact that doctors are prescribing these combinations of medications although some people might of the combinations are already rejected or have yet to be authorized by the FDA.

Seizures really are a side effect with Contrave and shouldn't be taken in individuals with seizure disorders. The drug also can raise hypertension and heart rate, and must not be used in individuals with a history of cardiac arrest or stroke in the earlier six months. Blood pressure and pulse should also be measured before starting the drug and throughout therapy using the drug.

The FDA also warned that Contrave can raise blood pressure and heart rate and must not used in patients with uncontrolled high blood pressure, along with by you aren't heart-related and cerebrovascular (circulation system dysfunction impacting the mind) disease. Patients having a history of cardiac event or stroke in the previous six months, life-threatening arrhythmias, or congestive heart failure were excluded through the clinical trials. Those taking Contrave should have their heart-rate and pulse monitored regularly. In addition, since the compound includes bupropion, Contrave comes using a boxed warning to alert medical professionals and patients for the increased probability of suicidal thoughts and behaviors associated with antidepressant drugs. The warning also notes that serious neuropsychiatric events happen to be reported in patients taking bupropion for stop smoking.


Acamprosate also activly works to eliminate the want to drink through the elimination of the the cravings for having a drink. The major difference between Naltrexone and Acamprosate is always that Acamprosate is just not yet for sale in the United States. While it continues to be widely studied in Europe the complete chemical believe that it works is still unknown. It is thought that it inhibits receptors inside the brain which process glutamate, which in effect alters the way in which ones body reacts to alcohol intake. Several of the European research has revealed a lot of promise with Acamprosate in that some of the patients had a nearly double rate of success for staying sober.